| Characteristics | Univariate analysis | Multivariate analysis | ||
| Univariable HR (95% CI) | P value | Univariable HR (95% CI) | P value | |
| Age (years) <60 versus ≥60 | 0.62 (0.29 - 1.35) | 0.23 | 0.21 (0.06 - 0.69) | 0.01 |
| Sex Male versus Female | 1.5 (0.61 - 3.72) | 0.38 | 2.28 (0.55 - 9.42) | 0.25 |
| PS 0 - 1 versus 2 | 0.65 (0.39 - 1.79) | 0.65 | 0.84 (0.29 - 2.49) | 0.76 |
| T stage T1/T2 versus T3/T4 | 0.7 (0.34 - 1.46) | 0.34 | 0.69 (0.25 - 1.91) | 0.48 |
| N stage N0/N1 versus N2/N3 | 0.91 (0.42 - 1.96) | 0.8 | 0.56 (0.19 - 1.66) | 0.29 |
| Number of metastasis 1 - 3 versus 4 - 5 | 1.4 (0.63 - 3.16) | 0.41 | 0.83 (0.22 - 3.1) | 0.77 |
| EGFR Negative versus Positive | 0.99 (0.58 - 1.67) | 0.95 | 1.76 (0.76 - 4.1) | 0.19 |
| ALK Negative versus Positive | 1.88 (0.88 - 4.04) | 0.12 | 2.46 (0.87 - 6.97) | 0.09 |
| CNS metastasis Yes versus No | 4.21 (1.07 - 16.66) | 0.04 | 13.9 (2.68 - 72.24) | 0.002 |
| Site of metastasis Single organ versus Multiple organ | 1.98 (0.89 - 4.42) | 0.09 | 1.96 (0.67 - 5.69) | 0.22 |