Characteristics

Univaiate analysis

Multivariate analysis

Univariable HR

(95% CI)

P value

Univariable HR (95% CI)

P value

Age (years)

<60 versus ≥60

1.24 (0.58 - 2.6)

0.58

0.23 (0.06 - 0.81)

0.02

Sex

Male versus Female

2.21 (0.89 - 5.48)

0.09

1.9 (0.44 - 8.16)

0.39

PS

0 - 1 versus 2

1.24 (0.57 - 2.68)

0.59

1.42 (0.48 - 4.19)

0.52

T stage

T1/T2 versus T3/T4

0.95 (0.45 - 1.99)

0.88

0.83 (0.28 - 2.42)

0.73

N stage

N0/ N1 versus N2/N3

0.78 (0.36 - 1.67)

0.52

0.44 (0.15 - 1.26)

0.12

Number of metastasis

1 - 3 versus 4 - 5

0.83 (0.22 - 3.1)

0.77

0.66 (0.13 - 3.38)

0.62

EGFR

Negative versus Positive

1.2 (0.71 - 2.05)

0.49

2.17 (0.79 - 5.98)

0.13

ALK

Negative versus Positive

1.78 (0.85 - 3.76)

0.13

2.47 (0.86 - 7.18)

0.09

CNS metastasis

Yes versus No

1.56 (0.45 - 5.45)

0.49

40.9 (6.1 - 276.4)

<0.001

Site of metastasis

Single organ versus Multiple organ

2.93 (1.29 - 6.65)

0.01

2.76 (0.84 - 9.12)

0.09