| ADE (incidence %) | REFERENCES | |||||||
| Middleton et al. 199824 | Nowak et al. 200825 | Vogelzang et al. 20033 Pemetrexed + Cisplatin 226 | Vogelzang et al. 20033 Cisplatin | Burzynski et al. 2014 | ||||
| Grades | Grades | Grades | Grades | Grades | ||||
| 3 | 4 | 3 | 4 | 3/4 | 3/4 | 3 | 4 | |
| General |
|
|
|
|
|
|
|
|
| Fatigue |
|
|
|
| 10.2 | 8.6 | 7.7 |
|
| Fever |
|
|
|
| 1.3 |
|
|
|
| Infection | 5.4 | - | 4 | - | 1.3 | 0.5 | 15.4 |
|
| Hematologic |
|
|
|
|
|
|
|
|
| Hemoglobin | 2.7 | - | 7 | - | 4.8 |
|
|
|
| Leukopenia | 10.8 | 2.7 | 30 | 6 | 17.7 | 0.9 | 7.7 |
|
| Lymphopenia |
|
|
|
|
|
|
|
|
| Neutropenia |
|
| 32 | 24 | 27.9 | 2.3 | 7.7 |
|
| Thrombocytopenia | 2.7 | - | 17 | 32 | 5.8 |
|
| 7.7 |
| Gastrointestinal |
|
|
|
|
|
|
|
|
| Anorexia |
|
|
|
| 2.2 | 0.5 | 7.7 |
|
| Constipation | 2.7 | - |
|
|
|
|
|
|
| Diarrhea | - | - | 2 | - | 4.4 |
| 15.4 |
|
| Dyspepsia |
|
|
|
|
|
|
|
|
| Dehydration |
|
|
|
| 4.0 | 0.5 |
|
|
| Mucositis | - | - |
|
|
|
| 7.7 |
|
| Nausea/vomiting | 8.1 | - | 20/17 | - | 14.6/13.3 | 6.3/3.6 | −/7.7 |
|
| Stomatitis |
|
| - | - | 4 |
|
|
|
| Cardiovascular |
|
|
|
|
|
|
|
|
| Hypertension |
|
|
|
|
|
| 7.7 |
|
| Chest pain |
|
|
|
|
|
| 7.7 |
|
| Neurologic |
|
|
|
|
|
|
|
|
| Paresthesia |
|
|
|
|
|
| 7.7 |
|
| Other |
|
| 13 | - |
|
|
|
|
| Dermatologic |
|
|
|
|
|
|
|
|
| Rash |
|
|
|
| 1.3 |
|
|
|
| Metabolic |
|
|
|
|
|
|
|
|
| Hypokalemia |
|
|
|
|
|
| 7.7 |
|