Treatment

Paw inflammation (mm) over the time after treatment (hour)

1

3

5

7

24

Sham

0.01 ± 0.00^$$$

−0.03 ± 0.01^$$$

−0.02 ± 0.00^$$$

−0.03 ± 0.01^$$$

−0.01 ± 0.01^$$$

CFA

2.84 ± 0.14

2.63 ± 0.19

2.63 ± 0,23

2.87 ± 0.12

2.58 ± 0.16

CFA + Indo 5 mg/kg

2.27 ± 0.17

1.70 ± 0.10**

1.79 ± 0.13**

1.50 ± 0.19***

1.70 ± 0.12**

CFA + AE 100 mg/Kg

3.19 ± 0.30

3.02 ± 0.22

2.63 ± 0.24

3.07 ± 0.31

2.74 ± 0.21

CFA + AE 200 mg/kg

2.73 ± 0.17

2.70 ± 0.25

2.89 ± 0.31

2.83 ± 0.32

2.70 ± 0.28