MMP member

Collagen types of the proteins being substrates

Remarks

MMP-1

I, II, III

when gene is mutated, member is associated with obstructive pulmonary disease (COPD) [61]

MMP-2

IV, V, elastin

when gene is mutated, member is associated with Winchester syndrome, Nodulosis-Arthropathy-Osteolysis (NAO) syndrome [62]

MMP-3

III, IV, IX, X

involved in wound healing, progression of atherosclerosis, tumor initiation [63]

MMP-8

I, II, III

involved in embryonic development, reproduction, tissue remodelling, arthritis, metastasis [64]

MMP-9

IV, V

animal studies suggest member is involved in tumor associated tissue remodelling [65]

MMP-10

fibronectin, elastin, proteoglycan core protein, laminin and some collagen types to be confirmed

involved in tissue remodelling, arthritis, metastasis [66]

MMP-13

I, II, III

involved in articular cartilage turnover and its pathology [67]

MMP-14

I, II, III, fibronectin, vitronectin

also known as membrane type MMP (MT-MMP); expressed at the cell membrane and is activated when cleaved by ECM proteinase. This member also activates MMP-2 and is suggested to be involved in tumor invasion [68] [69]

MMP-15

ProMMP-2, fibronectin, laminin, very small amount of I

this member is also an MT-MMP; suggested to be involved in tissue remodelling, development, reproduction, arthritis and metastasis [69] [70]

MMP-16

III, ProMMP-2, gelatin, fibronectin, laminin

this member is also an MT-MMP; suggested to be also involved in tissue remodelling, development, reproduction, arthritis and metastasis [69]