PT

Wang L et al. [1]

Zhao X et al. [10]

Wu C et al. [35]

Fogarty et al. [54]

NA (total of 339 patients)

NA (total 53.000 patients)

NA (total 201 patients)

NA (total of 83 patients)

<0.001

0.628

<0.01

0.11

Yes

No

Yes

No

Decreased blood platelets

Zhao X et al. [10]

Lippi G et al. [57]

NA (total 53.000 patients)

NA (total of 1779 patients)

<0.001

<0.001

Yes

Yes

Elevated hs-TpI

Wang L et al. [1]

Zhou F et al. [7]

Zhao X et al. [10]

Du R-H et al. [43]

NA (total of 339 patients)

NA (total of 191 patients)

NA (total 53.000 patients)

NA (total of 179 patients)

<0.001

0.026

<0.001

<0.001

Yes

Yes

Yes

Yes

Procalcitonin increased

Wang L et al. [1]

Liu W et al. [6]

Li K et al. [41]

Zhao X et al. [10]

Zhang JJ et al. [25]

NA (total of 339 patients)

NA (total of 78) patients

44/83 patients (53.0%)

NA (total 53.000 patients)

41/118 patients (34.7%)

<0.001

0.696

0.001

0.007

0.004

Yes

No

Yes

Yes

Yes

CRP increased

Wang L et al. [1]

Liu W et al. [6]

Li K et al. [41]

Zhao X et al. [10]

Zhang JJ et al. [25]

Wu C et al. [35]

NA (total of 339 patients)

NA (total of 78 patients)

50/83 patients (60.2%)

NA (total 53.000 patients)

125/136 patients (91.9%)

NA (total of 201 patients)

<0.001

0.028

0.001

<0.001

0.199

0.008

Yes

Yes

Yes

Yes

No

Yes

Liver enzyme elevations

Wang L et al. [1]

Zhao X et al. [10]

Wu C et al. [35]

Zhang Y et al. [68]

NA (total of 339 patients)

NA (total 53.000 patients)

NA (total of 201 patients)

NA (total 115 patients)

<0.001

0.001

> 0.05

0.001

Yes

Yes

No

Yes

Albumin Levels

Liu W et al. [6]

Zhao X et al. [10]

Wu C et al. [35]

NA (total of 78 patients)

NA (total 53.000 patients)

NA (total of 201 patients)

0.003

0.019

<0.001

Yes

Yes

Yes