Prognosis factor

Author’s

Number of patients

p value

Associated with a worse prognosis?

Older age

Wang L et al. [1]

Liu W et al. [6]

Zhou F et al. [7]

Zhao X et al. [10]

Zhang JJ et al. [25]

Wu C et al. [35]

Li K et al. [41]

339/339 patients (100%)

15/78 patients (≥60 years) (19.2%)

NA (total of 191 patients), MA 56 years

NA (total of 53.000 patients), median age 49.8

98/140 patients (≥50 years) (70%)

NA (total of 201 patients)

NA (total of 83 patients), median age 45.5

<0.001

0.011

0.0043

<0.001

<0.001

<0.001

<0.001

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Sex

Zhao X et al. [10]

Zhang JJ et al. [25]

Wu C et al. [35]

29.150/53.000 patients (M) (55%)

44/140 patients (F) (31.4%)

128/201 patients (63.7%)

<0.001

0.219

>0.005

Yes

No

No

CVD

Wang L et al. [1]

Zhou F et al. [7]

Li K et al. [41]

Zhao X et al. [10]

Zhang JJ et al. [25]

53/ 339 patients (15.6%)

15/191 patients (7.9%)

1/83 patients (1.2%)

1431/53.000 patients (2.7%)

7/140 patients (5.0%)

<0.001

0.48

<0.001

0.002

0.448

Yes

No

Yes

Yes

No

Hypertension

Wang L et al. [1]

Li K et al. [41]

Zhao X et al. [10]

Zhang JJ et al. [25]

Wu C et al. [35]

138/ 339 patients (40.7%)

5/83 patients (6.0%)

10.070/53.000 patients (19.0%)

42/140 patients (30.0%)

23/84 patients (27.4%)

0.031

<0.001

<0.001

0.085

0.001

Yes

Yes

Yes

No

Yes

DM

Li K et al. [41]

Zhao X et al. [10]

Zhang JJ et al. [25]

Wu C et al. [35]

7/83 patients (8.4%)

4346/53.000 patients (8.2%)

17/140 patients (5.0%)

16/84 patients (19.0%)

<0.001

<0.001

0.615

0.002

Yes

Yes

No

Yes

Smoking

Liu W et al. [6]

Zhao X et al. [10]

Zhang JJ et al. [25]

5/78 patients (6.4%)

NA (total 53.000 patients)

9/140 patients (6.4%)

0.011

0.663

0.448

Yes

No

Yes

Malignancy

Wang L et al. [1]

Zhao X et al. [10]

15/339 patients (4.4%)

NA (total 53.000 patients)

0.12

0.309

No

No

COPD

Wang L et al. [10]

Li K et al. [41]

Zhao X et al. [10]

Zhang JJ et al. [25]

21/339 patients (6.2%)

5/83 patients (6.0%)

NA (total 53.000 patients)

2/140 patients (1.4%)

<0.001

<0.001

0.004

0.170

Yes

Yes

Yes

No

Eosinopenia

Zhang JJ et al. [25]

73/138 patients (52.9%)

0.165

No

Lymphocyte count decreased

Wang L et al. [1]

Li K et al. [41]

Zhao X et al. [10]

Zhang JJ et al. [25]

Wu C et al. [35]

Du R-H et al. [51]

NA (total of 339 patients)

44/83 patients (53.0%)

28.991/53.000 patients (54.7%)

104/138 patients (75.4%)

NA (total of 201 patients)

NA (total of 179 patients)

<0.001

<0.001

<0.001

0.160

<0.001

<0.001

Yes

Yes

Yes

No

Yes

Yes

D-dimers

Wang L et al. [1]

Zhou F et al. [7]

Zhao X et al. [10]

Zhang JJ et al. [25]

Wu C et al. [35]

NA (total of 339 patients)

NA (total of 191 patients)

NA (total 53.000 patients)

35/81 patients (43.2%)

NA (total of 201 patients)

<0.001

0.0033

<0.001

0.004

<0.05

Yes

Yes

Yes

Yes

Yes