Factors affecting the risk of bleeding in patients with AF receiving an oral anticoagulant [67]

Baseline risk factors for fatal bleeding during VTE treatment [68]

Intensity of anticoagulation

Age > 75 years


Metastatic cancer

History of stroke

Immobility ≥ 4 days

Previous bleeding

Major bleeding event within the past 30 days


Abnormal prothrombin time

Co-morbidities (e.g. hypertension, renal insufficiency, hepatic disease)

Platelet count < 100 × 109/l

Co-medications (e.g. antiplatelets, NSAIDs)

CrCl < 30 ml/min

Lifestyle (e.g. alcohol consumption)