Non-VKA OACs should not be used in patients who

Have active clinically significant bleeding

Have CrCl < 15 ml/min^*

Are receiving concomitant treatment with any other anticoagulant

Have hepatic disease associated with coagulopathy and/or clinically relevant bleeding risk^†

Are < 18 years of age

Are pregnant or breastfeeding

Have prosthetic heart valves

Have haemodynamically unstable pulmonary embolism or require thrombolysis or pulmonary embolectomy