Indication	Apixaban	Dabigatran	Edoxaban	Rivaroxaban
VTE prevention after major orthopaedic surgery*
Hip	2.5 mg bid	220 mg od	O	10 mg od
Knee	2.5 mg bid	220 mg od	O	10 mg od
VTE treatment^†
DVT	10 mg bid for 7 days and 5 mg bid thereafter	150 mg bid, following treatment with a parenteral anticoagulant for ≥5 days	60 mg od, following treatment with a parenteral anticoagulant for ≥5 days	15 mg bid for 21 days and 20 mg od thereafter
PE	10 mg bid for 7 days and 5 mg bid thereafter
VTE secondary prevention	2.5 mg bid
Stroke prevention in patients with AF^‡	5 mg bid	150 mg bid	60 mg od	20 mg od
Acute coronary syndrome^§	O	O	O	2.5 mg bid