(n = 257)

1

10

(12.5)

25

(24.0)

14

(19.2)

2

21

(26.3)

29

(27.9)

17

(23.3)

3

30

(37.5)

27

(26.0)

26

(35.6)

4

12

(15.0)

13

(12.5)

6

(8.2)

Headache

0

43

(53.8)

52

(50.5)

38

(51.4)

0.365

(n = 257)

1

12

(15.0)

27

(26.2)

12

(16.2)

2

13

(16.3)

14

(13.6)

8

(10.8)

3

11

(13.8)

9

(8.7)

15

(20.3)

4

1

(1.3)

1

(1.0)

1

(1.4)

Backache

0

17

(21.3)

36

(34.3)

25

(33.3)

0.320

(n = 260)

1

15

(18.8)

11

(10.5)

9

(12.0)

2

18

(22.5)

29

(27.6)

15

(20.0)

3

21

(26.3)

20

(19.0)

21

(28.0)

4

9

(11.3)

9

(8.6)

5

(6.7)

Constipation

0

49

(61.3)

55

(52.9)

37

(49.3)

0.602

(n = 259)

1

15

(18.8)

22

(21.2)

14

(18.7)

2

13

(16.3)

20

(19.2)

18

(24.0)

3

2

(2.5)

3

(2.9)

5

(6.7)

4

1

(1.3)

4

(3.8)

1

(1.3)

Diarrhea

0

47

(59.5)

56

(53.3)

38

(50.7)

0.462

(n = 259)

1

13

(16.5)

26

(24.8)

14

(18.7)

2

12

(15.2)

19

(18.1)

13

(17.3)

3

5

(6.3)

3

(2.9)

8

(10.7)

4

2

(2.5)

1

(1.0)

2

(2.7)

Abdominal distension

0

29

(36.3)

40

(38.1)

28

(37.8)

0.427

(n = 259)

1

22

(27.5)

26

(24.8)

17

(23.0)

2

22

(27.5)

32

(30.5)

16

(21.6)

3

6

(7.5)

4

(3.8)

10

(13.5)

4

1

(1.3)

3

(2.9)

3

(4.1)

Nausea

0

68

(85.0)

86

(81.9)

60

(81.1)

0.568

(n = 259)

1

6

(7.5)

8

(7.6)

5

(6.8)

2

5

(6.3)

5

(4.8)

2

(2.7)

3

0

(0.0)

4

(3.8)

5

(6.8)

4

1

(1.3)

2

(1.9)

2

(2.7)

Edema

0

35

(43.8)

41

(39.0)

34

(45.9)

0.803

(n = 259)

1

21

(26.3)

34

(34.0)

17

(23.0)

2

18

(22.5)

25

(23.8)

15

(20.3)

3

5

(6.3)

4

(3.8)

7

(9.5)

4

1

(1.3)

1

(1.0)

1

(1.4)