Placebo/Edivoxetine

Edivoxetine/Edivoxetine

All Patients

Measure (Unit)/Criteria

N

n (%)

N

n (%)

N

n (%)

Elevated Any Time

SDP of ≥140 mm Hg and an increase of ≥20 mm Hg from baseline

195

20 (10.3)

92

4 (4.4)

287

24 (8.4)

DBP of ≥90 mm Hg and an increase of ≥10 mm Hg from baseline

195

54 (27.7)

92

24 (26.1)

287

78 (27.2)

Pulse > 100 beats per minute (bpm) and an increase of ≥15 bpm from baseline.

195

109 (55.9)

92

35 (38.0)

287

144 (50.2)

Sustained Elevation at 3 Consecutive Visits

SDP of ≥140 mm Hg and an increase of ≥20 mm Hg from baseline

185

2 (1.1)

86

0

271

1 (0.7)

DBP of ≥90 mm Hg and an increase of ≥10 mm Hg from baseline

185

22 (11.9)

86

8 (9.3)

271

30 (11.1)

Pulse >100 beats per minute (bpm) and an increase of ≥15 bpm from baseline

185

46 (24.9)

86

8 (9.3)

271

54 (20.0)

Potentially Clinically Significant, Any Time

SDP of ≥180 mm Hg and an increase of ≥20 mm Hg from baseline

195

0

92

0

287

0

DBP of ≥105 mm Hg and an increase of ≥15 mm Hg from baseline

195

6 (3.1)

92

2 (2.2)

287

2 (2.8)