Internal origin (attributes of the organization)


1) Possession of mycothiol.

2) Highly contagious at low dosage.

3) High cell wall content of mycolic acid.

4) Replicates in alveolar macrophages.

5) Extrapulmonary multiorgan involvement.

6) Dual polymorphism.

7) Variable metabolic states.

8) Delayed seeding of the bacterium to the mediastinal lymph nodes.

9) Delayed macrophage apoptosis.

10) Intrinsic resistance of the latent bacilli.

11) Shifts to glyoxylate pathway during lipid metabolism in lieu of glucose.


1) Establishes productive infection in only 10% of infected subjects.

2) Requires host membrane proteins Rv3671c during in vivo replication.

3) M. tb is a strictly aerobic intracellular pathogen.

4) Variable levels of ATP.

External origin (attributes of the organization)


1) Antibiotic resistance owing to inappropriate drug treatment.

2) Smoking and alcohol consumption.

3) Limited efficacy of BCG Vaccine in adults.

4) Limited facility for diagnosis of TB.

5) Pathogenic synergy of coinfection with HIV.

6) Immune status of the host.

7) Immigration.

8) Malnutrition, poverty, undignified living conditions.

9) Anatomical vulnerability of the lungs.


1) Development and application of infecton.

2) Inauguration of annual TB tests.

3) Selective isolation and reintroduction of Sanatoria.

4) Prioritizing genomic drug targets.

5) Sustenance of the global TB funds.

6) Development of potent vaccine.

7) Characterising TB using live imaging by computer tomography and positron electron micrography.

8) Development and use of sensitive microbiological tests as gold standard.