Reference

No.

of pts

Stage or selection criteria

Dose

(Gy)

No. of fractions and

overall treatment period

Macbeth et al. 2004 [13]

509

Inoperable non metastatic

17

39

2F in 8 days (1 week apart)

13F over 2 weeks and half

Sundstorm et al. 2004 [14]

421

Stage III-IV

17

42

50

2F in 8 days (1 week apart)

15F over 3 weeks

25F over 5 weeks

Simpson et al. 1985 [15]

409

Inoperable stage III B

30

40

10F over 2 weeks

20F over 4 weeks

MRC. 1991 [16]

369

Inoperable including

Metastases-ECOG

PS up to 2

17

27

30

2F in 8 days (1 week apart)

6F in 8 days

10 F in 2 weeks

Kramer et al. 2005 [7]

297

Stage III-IV

16

30

2F (1 week apart)

10F over 2 weeks

MRC. 1992 [17]

235

Locally advanced including

Metastases-PS ≥ 2

17

10

2F (1 week apart)

1F

Besjak et al. 2002 [18]

230

Locally advanced including

metastases

10

20

1F

5F over 1 week

Rees et al. 1997 [11]

216

Locally advanced including

metastases

17

22.5

2F in 8 days (1 week apart)

5F over I week

Senkus-Konfeica et al. 2005

[19]

100

Locally advanced including

metastases

20

16

5F over 1 week

2F (1 week apart)