| Single Hormone HCL System | Compatible CGM(s) | BG target in standard automated modes | BG targets in activity modes | Method(s) of insulin adjustment | User-adjustable settings in automated mode | Settings that cannot be adjusted in automated mode | FDA-approved? | Insulin requirements for auto mode |
| MiniMed 670G | Guardian 3, calibration required | 120 mg/dL | Exercise: 150 mg/dL | Basal modulation; pump may recommend bolus if BG ≥ 150 mg/dL but user must accept. System calculates the TDD over the past 6 and uses this to inform the basal rates and ISF. | I:C ratio DIA | Basal rates Target (except for exercise) ISF | Yes, age 7+ | 8 U - 250 U TDD |
| MiniMed 770G | Guardian 3, calibration required | 120 mg/dL | Exercise: 150 mg/dL | Basal modulation; pump may recommend bolus if BG ≥ 150 mg/dL but user must accept. System calculates the TDD over the past 6 days and uses this to inform the basal rates and ISF. | I:C ratio DIA | Basal rates Target (except for exercise) ISF | Yes, age 2+ | 8 U - 250 U TDD |
| MiniMed 780G | Guardian 3, planned release of updated sensor requiring no calibration | 100 mg/dL, can increase to 120 mg/dL | Exercise: 150 mg/dL | Basal modulation and automatic correction boluses q5 minutes. System calculates the TDD over the past 6 days at midnight and uses this to inform the basal rates and ISF. | I:C ratio DIA Target | Basal rates ISF | Not yet, (approved in Europe in June 2020); likely to start out at 7+ | 8 U - 250 U TDD |
| Tandem Control-IQ | Dexcom G6 | 112.5 mg/dL - 160 mg/dL; Correction target is 110 mg/dL | Sleep: 112.5 mg/dL - 120 mg/dL Exercise: 140 mg/dL - 160 mg/dL | Basal modulation of pre-set basal rates and automatic correction boluses q1 hour of 60% predicted need (correction boluses not administered in sleep mode). | I:C ratio ISF Basal rate TDD (this constrains the max basal rates) Target | DIA Correction target, can tighten range by running sleep | Yes, age 6+ | 10 U TDD minimum |
| CamAPS FX | Dexcom G6 | Default is 104 mg/dL but is adjustable (80 - 200 mg/dL); can be varied by time of day | Boost: for periods of increased insulin needs (i.e. atypical food intake, stress, illness) Ease off: for when less insulin is needed (i.e. exercise); can be set in the future | Basal modulation | I:C ratio and ISF are used by the bolus calculator for meals and for user-initiated correction boluses in auto mode | Basal rates | No, but approved in UK/EU for age 1+ | 5 U - 350 U TDD; at least 10 kg |
| Omnipod 5 | Dexcom G6 | 110 - 150 mg/dL in 10 mg/dL increments; can be varied by time of day | Hypoprotect: 150 mg/dL | Basal modulation. Autobasals are based on estimated and then actual TDD after initialization. | TargetISF, DIA (used for user-initiated correction boluses in auto mode, not autodelivered insulin) | Basal rates | Submitted | None mentioned |
| Tidepool Loop | Many | Likely to be adjustable | Likely to be adjustable | Basal modulation | I:C ratio ISF Basal rate Target | DIA | No | None studied, seeking FDA approval from DIY Loop studies |
| Loop | Many | Adjustable | Adjustable | Basal modulation of the pre-set basal rates. Autobolus branch gives automatic correction boluses. | I:C ratio ISF, Basal rate Target | DIA (you choose the model based on age and type of insulin you use, can be modified with code adjustments) | No-DIY | None studied |
| AndroidAPS | Many | Adjustable | Adjustable | Basal modulation of the pre-set basal rates. Oref1 can give automated boluses. | I:C ratio ISF, Basal rateDIA, TargetAdvanced settings (max iob, autosensing, insulin curves, etc.) | N/A | No-DIY | None studied |
| OpenAPS | Many | Adjustable | Adjustable | Basal modulation of the pre-set basal rates. Oref1 can give automated boluses. | I:C ratio ISF, Basal rate Basal rate DIA, TargetAdvanced settings (max iob, autosensing, insulin curves, etc.) | N/A | No-DIY | None studied |