Upstream Regulator

Log₂ Fold changes

Predicted Activation State

Activation z-score

p-value of overlap

Target molecules in dataset

PPARG

−5.533

Activated

3.807

0.000011

ABCG2, ACSL1, ACSL4, ADIPOQ, ADRB2, AQP7, ATP2A2, BCL2, BIN1, CA2, CAV1, CD36, CIDEC, CPT1B, CSF3, CYP19A1, CYP4B1, DLK1, FABP1, FABP3, FAM57B, FGF1, FOXO6, GPAM, GPD1, HIVEP2, HK2, IGFBP1, IL6, IRS1, KLF11, LEP, LIPE, LPL, MBNL1, MGLL, MTTP, NDUFA5, NOX4, NR4A1, PC, PCK1, PDK4, PFKFB3, PLIN1, PLIN4, PLIN5, PPARA, PPARGC1A, PRKG2, RAPGEF1, RNF144B, SHBG, SLC25A20, SLC2A4, SORBS1, SPP1, TSC22D3, UCP3, VNN1

PPARD

−3.92

Activated

2.88

0.0015

ADORA1, APOA1, APOB, AQP7, BCL2, CD36, CPT1B, FABP1, FABP3, GOT2, GPAM, GPD1, GPD2, IGFBP1, IL6, LPL, MYOM2, PDE4C, PDK4, PLP1, PRKAG3, SLC25A20, STBD1, TCEA3, TNFRSF11B, TRIM63, UCP3, VLDLR

PPARA

2.334

Activated

3.055

0.00528

ABCD2, ACSL1, ACTA1, ADIPOQ, ALDH2, ALDOB, APOA1, AQP7, BCL2, C6, CD36, CDKN2C, CEACAM1, CFH, CIDEC, CPT1B, CXCL12, FABP1, FADS1, FADS2, FGB, FITM1, GOT2, GPAM, GPD1, GPD2, IGFBP1, IL6, LPL, MGLL, MTTP, PAQR9, PC, PCK1, PDK4, PLA2G7, PLIN1, PLIN4, PLIN5, PON1, PPARA, PRL, RBP7, RTN4, SLC25A20, STBD1, SYCP3, TMTC2, UCP3, VNN1

THRB

2.75

Activated

2.114

0.00282

ABCD2, APOA1, COX7A1, DDC, DKK1, FRZB, FZD4, FZD7, FZD9, IL6, LPL, MAPK8, MYH6, MYH7, NR4A1, PCK1, PHYH, PLIN1, PRL, SFRP4, STAT5B, TCEA3, THRB, THRSP, TSHR, UCP3, WNT11

ESRRG

9.576

Activated

2.881

4.56E−09

CYP19A1, FBXO32, FGF1, GAPDH, HK2, LDHA, LPIN1, LPL, MB, NRP1, PCK1, PDK4, PKM, TPI1, TRIM63, UCP3

AR

Activated

2.431

0.000009

ANKRD1, ATP2A2, AVPR1A, CACNA1C, CAMK2A, CASQ2, CAV1, CHRNA1, CHRNB1, CHRNG, CLCN1, CLDN11, CLGN, CSRP3, CXCL12, CYP11A1, DES, DYRK1A, ELOVL2, GFAP, GPR182, GUCY1A3, HSPB7, IL6, INHA, KCNJ3, KISS1R, KITLG, LMOD1, MEF2C, MME, MSTN, MYH6, MYL3, MYOD1, MYOG, MYOM1, MYOT, MYOZ2, NMRK2, NR3C1, PCDH11X, PCMT1, PDGFA, PIGR, PNMT, RAB3C, SCN4A, SCN9A, SHBG, SLC26A7, SLC7A4, SLCO3A1, SMYD1, SNAI3, SPP1, TACC2, TGFB2, TNNT2

PGR

Activated

3.17

0.000862

ABCG2, ACSL1, ADAMTS1, ALOX15, ATP1B1, BIRC2,

CD59, CDKN1C, CPT1B, CYP19A1, DDC, DST, ESR1,

GOT1, GRB10, IGFBP1, KLF11, KLF9, MFAP5, P2RY2,

PFN2, PNMT, PRKG2, PRL, PRRX1, SERPINA5, TSC22D3, ZEB1

ESRRA

Activated

4.835

0.00105

ACSL1, ATP2A2, B4GALT6, CACNB1, CD36, CPT1B, CSF3, CYP19A1, FABP3, GAPDH, GOT1, HK2, LDHA, LPL, MYH6, MYH7, PDP1, PKM, PNMT, PPARA, PPARGC1A, PPM1B, PPP1R1B, TCAP, TPI1, WNT11