195 studies from 44 countries

168,389 subjects

Overall proportion of M and F: 43.3% and 46.7%

Mean age 51.7 years (SD ± 24.3)

88.1% of the studies: average values of 25(OH)D < 30 ng/ml

37.3% of the studies: average values of 25(OH)D < 20 ng/ml

6.7% of the studies: average values of 25(OH)D < 10 ng/ml

North America Middle East/Africa studies: higher values of 25(OH)D.

Asia/Pacific studies: values of 25(OH)D significantly lower in children/adolescents

Asia/Pacific and Middle East Africa studies: values in women tend to be lower (no significant difference)

Institutionalized elderly and infants: low levels of 25(OH)D in numerous countries