Proband (Son)

MBC Patient (Father)

Classical Cytogenetics with GTG banding

Representative Karyotypes

43,Y,-X,-11,-12,-13,-16,+2mar/44,XY,-11,t(13;?)(q;?),+13,-14/45,XY,dic(2;6)(qter→p24::p23→qter), +6,chtb(9)(q2?),-11/45,XY,dic(21;22)(qter →p13?::p13?→qter)/45,XY,rob(13;14)(q10;q10)/45,XY,-4,+5,-6,+19,-20,-21,+mar/46,XY,del(1)(pter→q10:)[4]/Ring, Triradials, Polyploidy/46,XY[11]

45,X,-Y[2]/45,XY,-19/46,XY,-17,+21/45,XY,tas(1;21)(q44;q11.2),chtb(5)(q13),-12,+21/46,XY,tas(7;20)(q36;p13)/46,XY,add(4)(q?),add(7)(q?),+9,-12,+16,-22/84,XXYY,+X,+1,-4,-5,-7,-9,-10,-11,-11,-12,-14,-17,+19,-20,+21,-22/Polyploidy[10],dmin[2]/46,XY[11]

SNP-A Profile

Gain

Yp11.2, Yp11.3

Yq11.22.1

Loss

7q11-21

Yq11.22.2

CN-LOH

6p22.3-6p21.2

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