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Days

Control

1000 mg/Kg∙BW

3000 mg/Kg∙BW

5000 mg/Kg∙BW

Conjugated bilirubin (mg/l)

D0

D14

0.39 ± 0.02

0.41 ± 0.02

0.52 ± 0.05

0.51 ± 0.03

0.51 ± 0.03

0.56 ± 0.04

0.53 ± 0.04

0.64 ± 0.04

Total bilirubin (mg/l)

D0

D14

2.37 ± 0.15

2.09 ± 0.13

2.93 ± 0.25

3.15 ± 0.22

2.07 ± 0.08

4.23 ± 0.35**

2.81 ± 0.02

4.12 ± 0.04**

Creat (mg/l)

D0

D14

6.90 ± 0.22

7.05 ± 0.13

6.80 ± 0.28

7.09 ± 0.15

7.22 ± 0.18

8.05 ± 0.62

7.22 ± 0.25

8.97 ± 0.82

Uremia (g/l)

D0

D14

0.28 ± 0.03

0.41 ± 0.03

0.28 ± 0.02

0.33 ± 0.03

0.40 ± 0.04

0.45 ± 0.04

0.34 ± 0.06

0.42 ± 0.06*

Uricemia (mg/l)

D0

D14

50.74 ± 3.03

50.11 ± 2.51

52.23 ± 1.9

50.16 ± 1.93

50.22 ± 3.05

59.54 ± 2.2*

51.39 ± 0.83

58.04 ± 1.91**

AST (UI/L)

D0

D14

32.77 ± 3.38

33.3 ± 2.61

37.21 ± 3.67

47.77 ± 2.25

38.54 ± 2.05

41.82 ± 3.55

41.25 ± 2.98

48.95 ± 3.25

ALT (UI/L)

D0

D14

79.14 ± 3.17

76.85 ± 2.02

91.36 ± 3.41

109.26 ± 8.67

95.06 ± 3.95

112.22 ± 5.98

91.95 ± 3.71

110.05 ± 1.5*

ALP (UI/L)

D0

D14

43.97 ± 3.84

45.13 ± 6.13

51.68 ± 2.45

56.85 ± 3.38

43.97 ± 1.38

55.67 ± 3.472*

49.34 ± 2.24

59.08 ± 1.76*