Pharmacokinetic parameters

Dose of the test agent (mg/kg)

4.3

17.0

Model—independent parameters

C_max (mg/L)

4.3 ± 0.4

84.5 ± 1.2

t_max (h)

0.33 ± 0.06

0.33 ± 0.04

K_el (h⁻¹)

0.3 ± 0.04

0.27 ± 0.03

MRT (h)

3.36

1.85

AUC (mg∙h/L)

14.2 ± 1.8

59.4 ± 6.4

Model—dependent parameters

A (mg/L)

4.3 ± 0.25

K_el (h⁻¹)

0.3 ± 0.04

K_a (h⁻¹)

25.3 ± 4.0

T_1/2 (h)

2.31 ± 0.15

Cl (L/h)

0,072

V₁ (L)

0.24 ± 0.01