Pharmacokinetic parameters | Dose of the test agent (mg/kg) | |
2.1 | 4.3 | |
Model—independent parameters | ||
A1 (mg/L) | 15.0 ± 2.4 | 9.0 ± 0.4 |
B1 (mg/L) | 5.9 ± 0.5 | 6.0 ± 0.3 |
α (h−1) | 5.1 ± 0.4 | 1.93 ± 0.06 |
β (h−1) | 0.3 ± 0.02 | 0.4 ± 0.02 |
AUC∞ (mg*h/L) | 22.6 ± 2.3 | 18.1 ± 1.5 |
t1/2.α (h) | 0.136 ± 0.011 | 0.36 ± 0.01 |
t1/2.β (h) | 2.3 ± 0.15 | 1.73 ± 0.09 |
Cl (L/h) | 0.022 | 0.052 |
MRT (h) | 2.93 | 2.2 |
V1 (L) | 0.024 ± 0.004 | 0.067 ± 0.005 |
Model—dependent parameters | ||
Kel (h−1) | 0.9 ± 0.1 | 0.77 ± 0.03 |
K12 (h−1) | 2.82 ± 0.4 | 0.56 ± 0.02 |
K21 (h−1) | 1.66 ± 0.3 | 1.0 ± 0.06 |
χ | 0.52 | 0.24 |
V1 (L) | 0.024 ± 0.004 | 0.067 ± 0.005 |
Vss (L) | 0.065 | 0.105 |