Time line

Day 0

Day 8 Plasma Dox ng/ml

2 hour post IP dosage

Day 15 Plasma Dox ng/ml 2 hour post IP dosage

Day 16 Plasma Dox ng/ml

24 hour post IP dosage

End Day of the test

Plasma

Troponin ng/ml

Tumor Extract Fluorescence RFU (doxorubicin Content ng/g)

Implant Post/Pre Implant doxorubicin %

IP PBS (3)

0

LLOQ 3/3

0

LLOQ 5/5

0

LLOQ 5/5

0.06

LLOQ 2/3

2.5 ± 0.84 (56 ng/g)

IP Dox 7 × 2 mg/kg, total 14 mg/kg (5)

15.9 ± 4.6

16.2 ± 4.3

4.8 ± 1.6

0.026 LLOQ 2/5

3.4 ± 0.36 (71 ng/g)

STID 100 (5)

0.3

LLOQ 4/5**

0

LLOQ 5/5*

0

LLOQ 5/5*

0

LLOQ 5/5*

3.7 ± 0.7

(81 ng/g)**ΞΎ

24% 3/5 retrievable

Average Weight g

IP PBS (3)

20.2

21.7

22.2

22.5

IP Dox 7 × 2 mg/kg, total 14 mg/kg (5)

21 ± 1.1

19.5 ± 1.4

19.9 ± 2

20 ± 1.8

STID 100 (5)

20.6 ± 0.1

21.2 ± 0.1

21.5 ± 0.4

23.3 ± 0.5***