Time line | Day 0 | Day 8 Plasma Dox ng/ml 2 hour post IP dosage | Day 15 Plasma Dox ng/ml 2 hour post IP dosage | Day 16 Plasma Dox ng/ml 24 hour post IP dosage | End Day of the test | ||
Plasma Troponin ng/ml | Tumor Extract Fluorescence RFU (doxorubicin Content ng/g) | Implant Post/Pre Implant doxorubicin % | |||||
IP PBS (3) | 0 LLOQ 3/3 | 0 LLOQ 5/5 | 0 LLOQ 5/5 | 0.06 LLOQ 2/3 | 2.5 ± 0.84 (56 ng/g) | ||
IP Dox 7 × 2 mg/kg, total 14 mg/kg (5) | 15.9 ± 4.6 | 16.2 ± 4.3 | 4.8 ± 1.6 | 0.026 LLOQ 2/5 | 3.4 ± 0.36 (71 ng/g) | ||
STID 100 (5) | 0.3 LLOQ 4/5** | 0 LLOQ 5/5* | 0 LLOQ 5/5* | 0 LLOQ 5/5* | 3.7 ± 0.7 (81 ng/g)**ΞΎ | 24% 3/5 retrievable | |
Average Weight g | |||||||
IP PBS (3) | 20.2 | 21.7 | 22.2 | 22.5 | |||
IP Dox 7 × 2 mg/kg, total 14 mg/kg (5) | 21 ± 1.1 | 19.5 ± 1.4 | 19.9 ± 2 | 20 ± 1.8 | |||
STID 100 (5) | 20.6 ± 0.1 | 21.2 ± 0.1 | 21.5 ± 0.4 | 23.3 ± 0.5*** |