| Author, Year | Number of cases in study | Predictive Biomarker | Postulated Role in RCP pathogenesis |
| Tena-Suck et al. [51] 2009 | 40 ACPs | Ep-CAM , PTTG-1 | Ep-CAM expression may be involved with invasiveness and proliferation; PTGG-1 expression may suggest hypophyseal metaplasia |
| Ebrahimi et al. [52] 2013 | 43 | Osteonectin | Marker of tumor invasion and aggressive behavior |
| Gong et al. [53] 2014 | 45 ACPs | CXCL12/CXCR4 | Play a role in regulating the directional migration and proliferation of tumor cells |
| Stache et al. [54] 2014 | 66 ACPs, 21 PCPs | claudin-1(CLDN1) | Altered distribution of CLDN1 affects cell mobility and tumor invasiveness |
| Samis et al. [55] 2016 | 23 | miR-132 | Downregulation of miR-132 appears to be a marker of aggressiveness and also plays a role in epithelial-mesenchymal transition |
| Li et al. [56] 2016 | 50 | FABP5/CRABPII | FABP5/CRABPII determines cellular response to physiological level of retinoic acid which may be involved in tumor cell apoptosis |
| Wang et al. [57] 2017 | 65 ACPs | AnnexinA2 (AnxA2) | affects cell mobility and tumor progression |