Differential diagnosis | Age | Presentation | Malignancy | Recurrence |
Leiomyoma | 25 - 54 years | Small (<3 cm), tan-white, well-circumscribed | Benign | None |
Leiomyosarcoma | Average 4th decade | 2 - 10 cm, infiltrative margin, vaginal bleeding | Malignant | High |
Angiomyofibroblastoma | Reproductive age | Small (<5 cm), tan-white, well-circumscribed | Benign, non-recurring | None |
Aggressive agiomyxoma | Reproductive age, median 4th decade | Large (>10 cm), soft, white, poor demarcation | Malignant | 30% - 40% recurrence if not completely excised |
Squamous cell carcinoma | Postmenopausal | Vaginal bleeding, pain, infiltrative tumor | Malignant | Depends on stage. Poor survival rate |
Adenocarcinoma | 46 - 67 years | Polypoid to papillary +/− ulceration | Malignant | Depends on stage |