Differential diagnosis

Age

Presentation

Malignancy

Recurrence

Leiomyoma

25 - 54 years

Small (<3 cm), tan-white, well-circumscribed

Benign

None

Leiomyosarcoma

Average 4^th decade

2 - 10 cm, infiltrative margin, vaginal bleeding

Malignant

High

Angiomyofibroblastoma

Reproductive age

Small (<5 cm), tan-white, well-circumscribed

Benign, non-recurring

None

Aggressive agiomyxoma

Reproductive age, median 4^th decade

Large (>10 cm), soft, white, poor demarcation

Malignant

30% - 40% recurrence if not completely excised

Squamous cell carcinoma

Postmenopausal

Vaginal bleeding, pain, infiltrative tumor

Malignant

Depends on stage. Poor survival rate

Adenocarcinoma

46 - 67 years

Polypoid to papillary +/− ulceration

Malignant

Depends on stage