Selected Reports on Cellular Distribution and Expression of Microglial Neuropeptide Receptors in the Brain | ||||
Model | Species | Cellular or Receptor Distribution | Method | References |
Mixed primary rat neuronal cortical culture | Rat | 50% neurons 20% astrocytes Remaining part: microglia (CD11) | Immuno-histochemichal | [9] |
Whole brain | Human | 0.5% - 16% microglia In white matter > in gray matter | Immuno-histochemical | [10] [11] |
Whole brain | Rodent | 15% - 12% microglia In gray matter > in white matter | Immuno-histochemical | [10] [12] |
Cellular nuclei Cortex (82% of brain mass) Cerebellum (10% of brain mass) | Human | 50% neuronal 50% nonneuronal 19% of total brain cells: neurons Ca. 80% of total brain cells: nonneuronal cells 80% of total brain cells: neurons | Isotropic fractionation | [13] [14] [15] |
Enriched glia and neuronal culture | Rat | 10 fold in microglia vs. neurons or astrocytes and macrophages | CX3CR mRNA | [16] [17] |
Normal brain and spinal cord Traumatic brain injury | Rat Mice | OX1R OX1R | OX1R antibody OX1R mRNA OX1R antibody | [18] [19] |
Retinal Microglia , N9 | Rat | NPY1R, NPY2R | NPY1R mRNA, protein | [20] [21] [22] |
Spinal cord injury, microglia | Rat | CRFR1, CRFR2 | CRFR1 antibody CRFR2 antibody | [23] |