Selected Reports on Cellular Distribution and Expression of Microglial Neuropeptide Receptors in the Brain

Model

Species

Cellular or Receptor Distribution

Method

References

Mixed primary rat neuronal cortical culture

Rat

50% neurons

20% astrocytes

Remaining part: microglia (CD11)

Immuno-histochemichal

[9]

Whole brain

Human

0.5% - 16% microglia

In white matter > in gray matter

Immuno-histochemical

[10] [11]

Whole brain

Rodent

15% - 12% microglia

In gray matter > in white matter

Immuno-histochemical

[10] [12]

Cellular nuclei

Cortex (82% of brain mass)

Cerebellum

(10% of brain mass)

Human

50% neuronal

50% nonneuronal

19% of total brain cells: neurons

Ca. 80% of total brain cells: nonneuronal cells

80% of total brain cells: neurons

Isotropic fractionation

[13] [14] [15]

Enriched glia and neuronal culture

Rat

10 fold in microglia vs. neurons or astrocytes and macrophages

CX3CR mRNA

[16] [17]

Normal brain and spinal cord

Traumatic brain injury

Rat

Mice

OX1R

OX1R

OX1R antibody

OX1R mRNA

OX1R antibody

[18]

[19]

Retinal Microglia , N9

Rat

NPY1R, NPY2R

NPY1R mRNA, protein

[20] [21] [22]

Spinal cord injury, microglia

Rat

CRFR1, CRFR2

CRFR1 antibody

CRFR2 antibody

[23]