Cephalosporin allergic reaction |
If there is no good previous history for PCN or Cephalosporin allergies, give the Cephalosporin. |
If the history is suggestive for non-anaphylactic reaction to PCN or Cephalosporin, perform Cephalosporin graded challenge. |
If the history is confirmative for anaphylaxis to PCN or Cephalosporin, use an alternative or perform Cephalosporin desensitization. |
Graded challenge (provocation challenge): give 1/1000th to 1/10th of the therapeutic dose in a 30 minutes’ interval till reach the recommended dose. Desensitization refers to a process of giving a medication in a controlled and gradual manner, which allows the person to tolerate it temporarily without an allergic reaction. Several protocols are available for certain medications. |