| Drug Reaction | Clinical Features | Examples |
| Hematologic | Hemolytic anemia, Thrombocytopenia, Granulocytopenia | PCN, Quinine, Sulfa |
| Hepatic | Hepatitis, Cholestatic jaundice | Sulfanamides, Aminosalacylic Acid |
| Pulmonary | Pneumonitis, Lung Fibrosis | Nitrofurantoin, Blemomycin, Methotrexate |
| Renal | Interstitial Nephritis, Glomerulonephritis | PCN, Sulfa, Allopurinol |
| Vascular | Vasculitis, SLE | Hydralazine, Procainamide, Isoniazid |
| CNS | Meningitis | NSAID, IVIG |