Immune reaction

Effector cells

Examples

Type I

Ig-E

Mast cells

Acute Asthma, Acute Allergic Rhinitis, Anaphylaxis

Type II

Ig-G

Phagocytes

Natural Killer cells

Hemolysis

Type III

Ig-G

Complement

Serum Sickness, Drug Fever

Type IV

Type IV a

IFNγ, TNFα

Macrophages

T_H1 cells

Tuberculin Reaction, Contact Dermatitis, Eczema

Type IV b

IL-5, IL-4/IL-13

Eosinophils

T_H2 cells

Chronic Asthma, Chronic Allergic rhinitis

Type IV c

Perforin/GranzymeB

T cells

Contact Dermatitis, Maculopapular or Bullous Exanthem, Hepatitis

Type IV d

CXCL-8.

GM-CSF, IL-17

Neutrophils

T cells

AGEP, TEN, SJS, Behçet Disease