| Date | Author | Event | Nosology associated with the concept of LTBI |
| 1839 | Schönlein | Designation of tuberculosis |
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| 1882 | Koch | Discovery of Koch’sbacillus |
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| 1890 | Koch | |
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| 1895 | Röntgen | Discovery or radiology |
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| 1896 | Bouchard | Description of radiological lesions of pulmonary tuberculosis |
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| 1897 | Kelschand Boinon | Description of the radiological anomalies indicative of tuberculosis in asymptomatic carriers | “LTBI” means subclinical tuberculosis |
| 1907 | Von Pirquet | Cutaneous tuberculin test of Von Pirquet (scarification) |
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| 1907 | Mantoux | Intradermalreactionto tuberculin |
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| 1909 | Mendel and Moro-Hamburger | Test of Mendel and of Moro-Hamburger |
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| 1910 | Mantoux | First study of the prevalence of tuberculosis infections in healthy subjects | “Tuberculosis infection” |
| 1916 | Ranke | Theory of the 3 stages of Ranke | “Primary tuberculosis infection” |
| 1926 | Am Journ Public Health | Performance of tuberculin tests in 51679 heads of cattle | “Nascent or undevelopped cases” |
| 1926 | Calmette, Valtis and Lacomme | Experimental inoculation of rabbits by BK | “Sligt or transcient infection” |
| 1943 | Waksman | Discovery of streptomycin |
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| 1946 | Canetti | Publication of “Tuberculosis allergy in man” | “Tuberculosis allergy” |
| 1951 |
| Commercialisation of isoniazid |
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| 1952 | OMS | Standardization of the production and administration of tuberculin |
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| 1954 | Canetti | Publication of “Primary-infection and reinfection in pulmonary tuberculosis» | “Prior-history of tuberculosis” |
| 1955 | Negre and Bretay | Publication of “Incompletely evolved Koch’s bacilli in tuberculosis infection” | “Abortive tuberculosis» |
| 1961 | Mount and Ferebee | First controlled trial, versus placebo, studying isoniazid in a population of children with positive tuberculin test | “Anti-tuberculosis chemoprophylaxis” |
| 1965 | Comstock and al | Double-bind, randomized, control study comparing prophylaxis by isoniazid with a placebo including 7033 residents in Alaska |
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| 1969 | Edwards and al | Tuberculin survey in the American navy from 1958 to 1965 | “Sensibilityto tuberculin” |
| 1975 | Rust and Thomas | Publication of “A method for estimating the prevalence of tuberculous infection” | “Tuberculosis infection” |
| 1985 | Am thor Society | Publication of “Treatment of tuberculosis and tuberculosis infection in adults and children.” | “Tuberculosis infection” |
| 2000 | Am Thor Society | Publication of”Targeted tuberculin testing and treatment of latent tuberculosis infection” | “Latent tuberculosis infection” |
| 2001 | Food and Drug administration | Approval of the use of QuantiFERON® |
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| 2015 | OMS | Publication of “Directives for the treatment of latent tuberculosis infection” |
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