P

Group II

Diabetes

with OAD other than metformin (n = 80)

Mean (SD) or n (%)

Group I

Diabetes with metformin

(n = 150)

Mean (SD) or n (%)

Variable

0.94 NS^!

48.15 ± 6.79

48.22 ± 6.86

Age (years)

0.38 NS^#

60 (75%)

20 (25%)

120 (80%)

30 (20%)

Sex:

Male

Female

0.42 NS^#

9 (11.25%)

12 (8%)

Smoking

0.08 NS^!

86.64 ± 3.89

88.00 ± 3.59

Weight (kg)

0.37 NS^!

31.96 ± 1.52

31.884 ± 1.53

BMI (kg/m²)

0.37 NS^!

135.58 ± 5.62

134.853 ± 5.86

Systolic Blood Pressure (mmHg)

0.06 NS^!

90.09 ± 3.08

89.32 ± 2.76

Diastolic Blood Pressure (mmHg)

0.39 NS^!

145.00 ± 5.99

144.02 ± 7.85

Fasting Blood Glucose (mg/dl)

<0.001**^!

7.60 ± 1.40

8.47 ± 0.87

Duration of diabetes (ys)

-

-

8.05 ± 1.50

Duration of metformin therapy (ys)

<4

>4

10 (6.7%)

140 (93.3 %)

-

-

1703.33 ± 261.30

Dose of metformin mg/day

<0.001**^!

8.01 ± 0.67

8.55 ± 0.64

HbA1c (%)

0.56 NS^!

88.23 ± 4.10

87.90 ± 3.98

Red cell MCV (76 - 95) fL

0.29 NS^!

15.10 ± 2.23

15.02 ± 2.51

Serum Folate (3.1 - 20.5) ng/ml

<0.001**^!

9.84 ± 3.42

14.45 ± 3.71

Homocystein (5.08 - 15.39) μmol/L

0.01*^$

2.73 ± 2.01

3.55 ± 2.56

Toronto clinical scoring system

0.04*^#

71 (88.8%)

7 (8.7%)

2 (2.5%)

113 (75.3%)

24 (16%)

13 (8.7%)

Neuropathy:

No Neuropathy

Mild Neuropathy

Moderate Neuropathy

<0.001**^!

381.55 ± 88.04

312.65 ± 92.28

Vitamin B12 (pg/Ml) Normal vitamin B12

Deficient vitamin B12

0.02*^#

72 (90%)

8 (10%)

116 (77.3%)

34 (22.7%)