| Characteristics | Objective Response Rate | Disease Control Rate | ||
| % | p Value | % | p Value | |
| Tobacco smoking Never smoker Smoker Former smoker |
0.0 37.5 11.5 | 0.060 |
50.0 62.5 46.2 | 0.560 |
| Brain local treatment Surgery or radiosurgery Whole brain radiation therapy None |
25.0 0.0 0.0 | 0.246 |
58.3 50.0 16.7 | 0.224 |
| Immunotherapy type Anti-CTLA-4 Anti-PD-1 Anti-PD-L1 |
0.0 15.0 60.0 | 0.056 |
33.3 52.5 60.0 | 0.866 |
| ECOG PS 0 - 1 ≥2 |
14.3 50.0 | 0.071 |
50.0 66.7 | 0.668 |
| Pathology Non-squamous Squamous |
17.9 22.2 | 0.990 |
48.7 66.7 | 0.466 |
| Mutation status Mutation No mutation |
17.4 15.4 | 0.990 |
43.5 53.8 | 0.549 |
| Brain metastases Synchronous Metachronous |
23.8 14.8 | 0.477 |
66.7 40.7 | 0.089 |
| Number of brain metastases at diagnosis 0 1 to 5 >5 |
14.8 25.0 20.0 | 0.660 |
40.7 62.5 80.0 | 0.170 |