Type

Payload/Examples

DNA Damaging Payloads

Double Strand Break Agents

Calicheamicin (gemtuzumab ozogamicin, inotuzumab ozogamicin)

Topoisomerase I Enzymes

Sacituzumab govitecan

Topoisomerase II Inhibitors

Doxorubicin, epirubicin, daunorubicin, idarubicin

Alkylating Agents

Duocarmycin, SYD983, SYD985

Crosslinkers

Pyrrolobenzodiazepines (PBD), Vadastuximab talirine

Payloads Inhibiting Tubulin Polymerization

Maytansinoids

Trastuzumab-MCC-DM1 (T-DM1), lorvotuzumab mertansine

Auristatins

Brentuximab vedotin, Polatuzumab vedotin