| Linker | Payload | Payload Class | Cyclic | Approval Status |
| Maleimidocaproyl (MC) | Monomethyl auristatin E (MMAE) | Auristatin | Yes | Approved |
| Maleimidocaproyl (MC) | Monomethyl auristatin F (MMAF) | Auristatin | Yes | Approved |
| Valine-citrulline (VC) | Monomethyl auristatin E (MMAE) | Auristatin | Yes | Approved |
| Valine-citrulline (VC) | Monomethyl auristatin F (MMAF) | Auristatin | Yes | Approved |
| Glucuronide | Monomethyl auristatins (MMAs) | Auristatin | Yes | Approved |
| Glucuronide | Maytansines (MTs) | Maytansine | Yes | Approved |
| Glucuronide | Duocarmycins (DCs) | Duocarmycin | Yes | Approved |
| Hydrazone | Monomethyl auristatins (MMAs) | Auristatin | Yes | Approved |
| Hydrazone | Maytansines (MTs) | Maytansine | Yes | Approved |
| Hydrazone | Duocarmycins (DCs) | Duocarmycin | Yes | Approved |
| Disulfide | Monomethyl auristatins (MMAs) | Auristatin | Yes | Approved |
| Disulfide | Maytansines (MTs) | Maytansine | Yes | Approved |
| Disulfide | Duocarmycins (DCs) | Duocarmycin | Yes | Approved |
| Click chemistry | Monomethyl auristatins (MMAs) | Auristatin | Yes | Approved |
| Click chemistry | Maytansines (MTs) | Maytansine | Yes | Approved |
| Click chemistry | Duocarmycins (DCs) | Duocarmycin | Yes | Approved |
| Click chemistry | Pyrrolobenzodiazepines (PBDs) | PBD | No | Approved |