| Nutritional and lifestyle interventions | EASL-EASD-EASO (2016) | AASLD (2018) | ESPEN (2019) |
| Ideal body weight | 7% - 10% total weight loss target in overweight/obese NAFLD cases | 7% - 10% total weight loss | · 7% - 10% weight loss in obese patients · >10% to improve fibrosis |
| Energy consumption | 500 - 1000 kcal/day | No specific recommendations | Hypocaloric diet (according to current obesity guidelines) |
| Macronutrient | · Low-to-moderate fat and moderate-to-high carbohydrate intake · Low-carbohydrate ketogenic or high-protein diets · Macronutrient should be adjusted according to Mediterranean diet | No specific recommendations | Mediterranean diet to improve steatosis and insulin sensitivity |
| Micronutrients | Short-term treatment with vitamin E (800 IU/day) for non-cirrhotic non-diabetic NASH cases | vitamin E for patients with advanced fibrosis and without diabetes mellitus | Specific vitamins, including vitamin A, D and K along with thiamine, folate and pyridoxine to correct deficiency |
| Fructose | Avoid | No specific recommendations | No specific recommendations |
| Alcohol | Strictly keep alcohol below the daily risk threshold (30 gm in men; 20 gm in women) | · Men: 21 standard drinks/week · Women: 14 standard drinks/week | Abstain, to reduce risk for comorbidity and to improve liver biochemistry and histology |