Treatment group

NT

D1

D2

N = 35

Mean

(SD)

Mean

(SD)

Difference vs NT

p-value

Mean

(SD)

Difference vs NT

p-value

iAUC^a_(0-15)

142.1

(105.1)

71.8

(48.5)

−70.3

(110.5)

0.001

80.6

(49.0)

−61.6

(109.8)

0.002

iAUC_(0-30)

635.8

(403.5)

357.2

(177.5)

−278.5

(337.7)

<0.001

432.9

(248.6)

−202.9

(300.1)

<0.001

iAUC_(0-45)

1407.4

(784.6)

841.1

(397.4)

−566.2

(558.2)

<0.001

992.1

(519.7)

−415.2

(484.7)

<0.001

iAUC_(0-60)

2162

(1112)

1350

(628.0)

−812.2

(750.9)

<0.001

1518

(727.5)

−644.2

(868.6)

<0.001

iAUC_(0-90)

3239

(1586)

2136

(964.6)

−1103

(1079)

<0.001

2289

(1034)

−950.5

(1092)

<0.001

iAUC_(0-120)

3951

(1876)

2619

(1210)

−1332

(1272)

<0.001

2815

(1274)

−1136

(1343)

<0.001

iAUC_(0-180)

4738

(2303)

3037

(1495)

−1701

(1503)

<0.001

3368

(1655)

−1370

(1601)

<0.001

Maximal concentration

69.3

(33.1)

47.0

(23.0)

−22.3

(22.9)

<0.001

51.3

(26.3)

−18.0

(17.3)

<0.001