Treatment group

NT

D1

D2

N = 35

Mean

(SD)

Mean

(SD)

Difference vs NT

p-value

Mean

(SD)

Difference vs NT

p-value

iAUCa(0-15)

10.9

(5.7)

5.6

(3.9)

−5.3

(5.3)

<0.001

6.6

(3.5)

−4.3

(6.1)

<0.001

iAUC(0-30)

45.0

(20.1)

28.2

(12.6)

−16.8

(16.6)

<0.001

29.3

(10.6)

−15.6

(18.4)

<0.001

iAUC(0-45)

80.7

(43.1)

53.0

(24.3)

−27.7

(28.8)

<0.001

52.0

(21.0)

−28.7

(36.6)

<0.001

iAUC(0-60)

102.6

(65.9)

68.7

(36.6)

−33.9

(44.7)

<0.001

64.3

(31.1)

−38.3

(57.9)

<0.001

iAUC(0-90)

123.1

(94.5)

82.2

(50.8)

−40.9

(69.9)

0.001

73.9

(43.7)

−49.2

(89.4)

0.003

iAUC(0-120)

133.1

(109.5)

87.2

(57.7)

−45.9

(84.8)

0.003

79.4

(51.8)

−53.7

(106.8)

0.005

iAUC(0-180)

141.8

(123.2)

90.7

(63.7)

−51.1

(122.3)

0.005

85.3

(60.2)

−56.4

(122.3)

0.010

Maximal concentrationb

8.35

(1.6)

7.5

(1.0)

−0.9

(1.0)

<0.001

7.4

(0.8)

−1.0

(1.2)

<0.001