Treatment group | NT | D1 | D2 | ||||
N = 35 | Mean (SD) | Mean (SD) | Difference vs NT | p-value | Mean (SD) | Difference vs NT | p-value |
iAUCa(0-15) | 10.9 (5.7) | 5.6 (3.9) | −5.3 (5.3) | <0.001 | 6.6 (3.5) | −4.3 (6.1) | <0.001 |
iAUC(0-30) | 45.0 (20.1) | 28.2 (12.6) | −16.8 (16.6) | <0.001 | 29.3 (10.6) | −15.6 (18.4) | <0.001 |
iAUC(0-45) | 80.7 (43.1) | 53.0 (24.3) | −27.7 (28.8) | <0.001 | 52.0 (21.0) | −28.7 (36.6) | <0.001 |
iAUC(0-60) | 102.6 (65.9) | 68.7 (36.6) | −33.9 (44.7) | <0.001 | 64.3 (31.1) | −38.3 (57.9) | <0.001 |
iAUC(0-90) | 123.1 (94.5) | 82.2 (50.8) | −40.9 (69.9) | 0.001 | 73.9 (43.7) | −49.2 (89.4) | 0.003 |
iAUC(0-120) | 133.1 (109.5) | 87.2 (57.7) | −45.9 (84.8) | 0.003 | 79.4 (51.8) | −53.7 (106.8) | 0.005 |
iAUC(0-180) | 141.8 (123.2) | 90.7 (63.7) | −51.1 (122.3) | 0.005 | 85.3 (60.2) | −56.4 (122.3) | 0.010 |
Maximal concentrationb | 8.35 (1.6) | 7.5 (1.0) | −0.9 (1.0) | <0.001 | 7.4 (0.8) | −1.0 (1.2) | <0.001 |