Parameter

Gentamicin

10 µg/ml

Interactant (concentration)

NaHCO₃ (0.25 mM)

Cimetidine (2 mM)

Cimetidine (2 mM) + NaHCO₃ (0.25mM)

GFR^a (ml/min/g)

0.52 (0.12)

0.48 (0.04)

0.43 (0.03)

0.32 (0.01)

Clearance (ml/min/g)^b

0.18 (0.03)

0.40 (0.09)^*,***

0.16 (0.03)^**

0.25 (0.04)^*

Excretion ratio^c

0.47 (0.11)

0.94 (0.22)^*

0.41 (0.05)^**,***

0.89 (0.16)^*

Cumulative excretion (% Dose)

26.2 (3.76)

47.7 (7.24)^*

21.7 (4.43)^**,***

36.0 (5.55)

Kidney accumulation^d (% Dose)

29.10 (3.32)

25.50 (7.34)^***

14.30 (1.22)^*,**

6.16 (0.74)^*

AUC_0-t^e

(min*µg/ml)

708 (32.0)

636 (16.1)

780 (27.1)^**

695 (72.2)