Parameter | Gentamicin 10 µg/ml | Interactant (concentration) | ||
NaHCO3 (0.25 mM) | Cimetidine (2 mM) | Cimetidine (2 mM) + NaHCO3 (0.25mM) | ||
GFRa (ml/min/g) | 0.52 (0.12) | 0.48 (0.04) | 0.43 (0.03) | 0.32 (0.01) |
Clearance (ml/min/g)b | 0.18 (0.03) | 0.40 (0.09)*,*** | 0.16 (0.03)** | 0.25 (0.04)* |
Excretion ratioc | 0.47 (0.11) | 0.94 (0.22)* | 0.41 (0.05)**,*** | 0.89 (0.16)* |
Cumulative excretion (% Dose) | 26.2 (3.76) | 47.7 (7.24)* | 21.7 (4.43)**,*** | 36.0 (5.55) |
Kidney accumulationd (% Dose) | 29.10 (3.32) | 25.50 (7.34)*** | 14.30 (1.22)*,** | 6.16 (0.74)* |
AUC0-te (min*µg/ml) | 708 (32.0) | 636 (16.1) | 780 (27.1)** | 695 (72.2) |