Viability parameter

Treatment groups

Control

drug naïve

NaHCO₃

Gentamicin 10 µg/ml

Gentamicin + NaHCO₃

Gentamicin + Cimetidine

Gentamicin + Cimetidine + NaHCO₃

Perfusion flow rate (ml/min)

22.7 (2.50)

24.8 (3.74)

29.0 (1.10)

23.5 (4.87)

23.7 (7.21)

28.9 (4.97)

Urine flow rate (ml/min)

0.06 (0.03)

0.12 (0.05)

0.11 (0.02)

0.12 (0.01)

0.08 (0.02)

0.11 (0.01)

Urine pH

7.2 (0.04)

8.1 (0.58)^*

7.1 (0.17)

8.1 (0.05)^*

7.0 (0.08)

8.2 (0.04)^*

GFR^a (ml/min/g)

0.49 (0.15)

0.51 (0.09)

0.52 (0.12)

0.48 (0.04)

0.43 (0.03)

0.32 (0.01)

FR_Glucose^b

0.96 (0.02)

0.94 (0.01)

0.97 (0.01)

0.93 (0.01)

0.95 (0.01)

0.88 (0.01)^**

FR_Sodium^c

0.94 (0.03)

0.86 (0.03)^*

0.88 (0.03)

0.85 (0.02)^*

0.94 (0.03)

0.84 (0.01)^*

FR_Chloride^d

0.92 (0.04)

0.86 (0.06)

0.85 (0.03)

0.87 (0.03)

0.91 (0.01)

0.85 (0.01)