Parameter

Gentamicin concentration

5 µg/ml

10 µg/ml

20 µg/ml

40 µg/ml

GFRa (ml/min/g)

0.57 (0.15)

0.52 (0.12)

0.46 (0.15)

0.45 (0.15)

Clearance (ml/min/g)b

0.14 (0.02)**

0.18 (0.03)**

0.08 (0.02)

0.09 (0.02)

Excretion ratioc

0.31 (0.05)

0.47 (0.11)**

0.26 (0.11)

0.26 (0.07)

Cumulative excretion (% Dose)

22.1 (1.75)**

26.2 (3.76)**

14.2 (3.21)

15.6 (1.81)

Kidney accumulation (% Dose)e

19.7 (4.92)

29.1 (3.32)*

26.5 (5.78)*

20.9 (5.18)

Dose normalized AUC0-t (min-µg/ml)e

1.0 (0.08)

0.94 (0.04)

1.1 (0.09)***

1.0 (0.02)