Parameter | Gentamicin concentration | |||||
5 µg/ml | 10 µg/ml | 20 µg/ml | 40 µg/ml | |||
GFRa (ml/min/g) | 0.57 (0.15) | 0.52 (0.12) | 0.46 (0.15) | 0.45 (0.15) | ||
Clearance (ml/min/g)b | 0.14 (0.02)** | 0.18 (0.03)** | 0.08 (0.02) | 0.09 (0.02) | ||
Excretion ratioc | 0.31 (0.05) | 0.47 (0.11)** | 0.26 (0.11) | 0.26 (0.07) | ||
Cumulative excretion (% Dose) | 22.1 (1.75)** | 26.2 (3.76)** | 14.2 (3.21) | 15.6 (1.81) | ||
Kidney accumulation (% Dose)e | 19.7 (4.92) | 29.1 (3.32)* | 26.5 (5.78)* | 20.9 (5.18) | ||
Dose normalized AUC0-t (min-µg/ml)e | 1.0 (0.08) | 0.94 (0.04) | 1.1 (0.09)*** | 1.0 (0.02) | ||