Viability parametera

Control

(drug-naïve)

Gentamicin concentration

5 µg/ml

10 µg/ml

20 µg/ml

40 µg/ml

Perfusion flow rate (ml/min)

22.7 (2.5)

23 (5.7)

29 (1.1)

28 (1.2)

24 (3.1)

Urine flow rate (ml/min)

0.06 (0.03)

0.10 (0.03)

0.11 (0.02)

0.10 (0.04)

0.08 (0.04)

Urine pH

7.2 (0.04)

7.3 (0.14)

7.1 (0.17)

7.1 (0.16)

7.3 (0.16)

GFRb (ml/min/g)

0.49 (0.15)

0.57 (0.15)

0.52 (0.12)

0.46 (0.15)

0.45 (0.15)

FRGlucosec

0.96 (0.02)

0.96 (0.01)

0.97 (0.01)

0.95 (0.02)

0.96 (0.02)

FRSodiumd

0.94 (0.03)

0.92 (0.04)

0.88 (0.03)

0.90 (0.05)

0.92 (0.07)

FRChloridee

0.92 (0.04)

0.89 (0.04)

0.85 (0.03)

0.88 (0.06)

0.90 (0.04)