Viability parameter^a

Control

(drug-naïve)

Gentamicin concentration

5 µg/ml

10 µg/ml

20 µg/ml

40 µg/ml

Perfusion flow rate (ml/min)

22.7 (2.5)

23 (5.7)

29 (1.1)

28 (1.2)

24 (3.1)

Urine flow rate (ml/min)

0.06 (0.03)

0.10 (0.03)

0.11 (0.02)

0.10 (0.04)

0.08 (0.04)

Urine pH

7.2 (0.04)

7.3 (0.14)

7.1 (0.17)

7.1 (0.16)

7.3 (0.16)

GFR^b (ml/min/g)

0.49 (0.15)

0.57 (0.15)

0.52 (0.12)

0.46 (0.15)

0.45 (0.15)

FR_Glucose^c

0.96 (0.02)

0.96 (0.01)

0.97 (0.01)

0.95 (0.02)

0.96 (0.02)

FR_Sodium^d

0.94 (0.03)

0.92 (0.04)

0.88 (0.03)

0.90 (0.05)

0.92 (0.07)

FR_Chloride^e

0.92 (0.04)

0.89 (0.04)

0.85 (0.03)

0.88 (0.06)

0.90 (0.04)