Group | First time | 6 months | 12 months | 24 months | ||||
Wheal | Erythema | Wheal (p value) | Erythema (p value) | Wheal (p value) | Erythema (p value) | Wheal (p value) | Erythema (p value) | |
N1 | 0.84 ± 0.24 | 2.01 ± 0.86 | 0.64 ± 0.28 (0.024) | 1.33 ± 0.66 (0.001)* | 0.72 ± 0.22 (0.111) | 1.42 ± 0.63 (0.001)* | 0.77 ± 0.13 (0.83) | 1.56 ± 0.48 (0.008)* |
N2 | 0.96 ± 0.35 | 2.70 ± 0.95 | 0.76 ± 0.28 (0.002)* | 2.25 ± 0.76 (0.006)* | 0.92 ± 0.22 (0.111) | 2.26 ± 0.74 (0.005)* | 0.92 ± 0.29 (0.233) | 2.37 ± 0.70 (0.029) |
N3 | 0.97 ± 0.35 | 2.42 ± 0.83 | 0.84 ± 0.30 (0.008)* | 1.54 ± 0.64 (0.001)* | 0.88 ± 0.33 (0.019) | 2.00 ± 0.70 (0.026) | 0.90 ± 0.34 (0.203) | 1.51 ± 0.57 (0.001)* |
N4 | 1.06 ± 0.42 | 2.46 ± 1.37 | 0.98 ± 0.36 (0.072) | 1.55 ± 0.64 (0.173) | 1.00 ± 0.44 (0.634) | 1.95 ± 1.34 (0.415) | 0.88 ± 0.41 (0.024) | 1.75 ± 0.90 (0.031) |