R

[8]

Q4WV22

Afu5g10520

alpha-1,2-mannosidase family protein

5

5

291

0.0090

8.29

R

[1] [16]

B0XU55

Afu2g14750

endo-arabinase

Transcript downregulated in response to voriconazole

6

5

203

0.0332

1.57

R

[1]

B0XV35

Afu2g14750

endo-arabinase

3

3

110

0.0055

1.72

S

[1] [16]

B0Y9W3

Afu8g05020, nagA

beta-n-acetylhexosaminidase

Highlyexpressed in biofilm

24

23

1188

0.0011

1.14

S

[1]

B0XYS2

AFUB_ 041890

putativeun characterized class v

40

36

2142

0.0000

1.46

R

[26]

Q875I9

csn

Endo-chitosanase

Sera from aspergilloma and IA patients recognized recombinant chitosanase in immunoblot, indicating expression during infection

7

7

463

0.0001

1.43

R

[27]

CHI1_ COCIM

cts1

Endochitinase 1 (complement-fixation antigen)

4

3

132

0.0027

4.31

R

[28]

F1DGF3_ ASPFM

bgl3

Extracellular beta-glucosidase/cellulase BGL3

21

21

1142

0.0061

1.35

S

[31]

MDHM_ YEAST

mdh1

Malate dehydrogenase, mitochondrial

14

13

553

0.0120

3.17

S

[8] [16]

ENO_ ASPFU

enoA

Enolase (AllergenAsp f 22)

Transcript induced by growth on hydrogen peroxide; hypoxia induced protein; transcript induced by exposure to human airway epithelial cells

6

6

294

0.0100

4.10

Glucanmetabolism

R

[1]

B0XYP2

Afu2g00430, exg9

Exo-beta-1,3-glucanase, putative

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation

13

13

511

0.0000

2.25

R

[1]

B0XMS4

Afu1g14450, exgO

Exo-beta-1,3-glucanase Exg0

14

13

1284

0.0006

1.58

R

[1]

B0XND8

Afu1g04260, engl1

endo-1,3-beta-glucanase engl1

12

12

447

0.0041

1.14

R

[1]

B0XSV7

Afu2g00690

Glucoamylase

5

4

210

0.0018

3.94

R

[1]

B0XXF8

eglC

Probable glucan endo-1,3-beta-glucosidase eglC

2

2

55

0.0178

6.96

R

[1]

B0YDR8

Afu6g01800

endoglucanase i

3

3

125

0.0039

1.90

R

[8]

[29]

[30]

GEL1_ ASPFU

gel1

1,3-beta- glucanosyltransferase gel1

Ÿ The antigens eliciting the highest frequencies of specific T cells producing IFN-c (protective immune response which mediates lysis of Aspergillus hyphae) is GEL1.

Ÿ Strenghtens cell wall assembly in stress conditions

Ÿ gel1 expression is markedly induced by exposure to voriconazole 0.5 mg/L

3

3

111

0.0144

1.01