S/R | [1] [16] [18] | B0YBR6 | AFUB_ 087580, aldA | aldehyde dehydrogenase | A whole-genome comparison performed on serial isolates from an aspergilloma patient revealed one itraconazole-resistant isolate which carried a mutation in aldA, together with five other nonsynonymous mutations, including the cyp51A mutation P216L Induced in neutrophil-exposed conidia; repressed by gliotoxin exposure | 12 | 9 | 569 | 0.0108 | 1.53 | ||
S | B0Y8I3 | AFUB_ 077440, aldA | aldehyde dehydrogenase AldA, putative | 10 | 8 | 422 | 0.0385 | 3.35 | ||||
R | [1] [8] [19] [20] [21] | SODC_ ASPFL | sodC | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) - Aspergillus flavus | Superoxide dismutases destroy toxic radicals which are normally produced within the cells Role in the resistance to phagocytic killing, but no decrease in virulence could be demonstrated for strains with mutations in three SOD genes in a murine IA model | 2 | 2 | 82 | 0.0497 | 2.17 | ||
S | [1] | B0Y6Y9 | Afu4g11580, sod2 | Mn superoxide dismutase | 4 | 4 | 137 | 0.0227 | 3.93 | |||
S | [8] | SODM_ ASPFU | sodB | Superoxide dismutase [Mn], mitochondrial precursor (AllergenAsp f 6) | 6 | 6 | 273 | 0.0232 | 4.33 | |||
S | [1] [20] [22] [23] [24] [25] | B0YAQ9 | Afu5g11320 | thioredoxin | A. fumigatus thioredoxin proteins function as antioxidants during infection; impair neutrophil-mediated fungal killing; are required for fungal growth during infection of the cornea Thioredoxin reductase, a different protein involved in the thioredoxin pathway is named as a possible new target for antifungal therapy, and as a potential biomarker for serological diagnosis Thioredoxins are cross-reactive allergens involved in the pathogenesis of atopic eczema and asthma Thioredoxin and thioredoxin reductase are regulated by the AP-1 like bZip transcription factor Yap1, which is involved in the antioxidative stress response and antifungal drug resistance in C. albicans | 3 | 2 | 58 | 0.0447 | 3.92 | ||
S | [8] | Q4WQZ2 | Afu4g14530 | glutathione s-transferase ure2-like protein, gstC | 9 | 2 | 406 | 0.0011 | 349.13 | |||
Carbohydrate metabolic process | ||||||||||||
R | [1] [16] | B0XM55 | Afu6g13760 | alpha-1,2-mannosidase subfamily | Transcript up-regulated in hyphae upon exposure to neutrophils | 7 | 7 | 257 | 0.0078 | 4.16 | ||
S | [1] | B0XQJ8 | Afu1g10790 | alpha-1,2-mannosidase family | 14 | 14 | 674 | 0.0000 | 2.84 | |||
R | [1] | B0YCI0 | Afu7g04720 | alpha-1,2-mannosidase, putative | 4 | 4 | 190 | 0.0105 | 2.52 | |||