S/R

[1]

[16]

[18]

B0YBR6

AFUB_ 087580, aldA

aldehyde dehydrogenase

Ÿ A whole-genome comparison performed on serial isolates from an aspergilloma patient revealed one itraconazole-resistant isolate which carried a mutation in aldA, together with five other nonsynonymous mutations, including the cyp51A mutation P216L

Ÿ Induced in neutrophil-exposed conidia; repressed by gliotoxin exposure

12

9

569

0.0108

1.53

S

B0Y8I3

AFUB_ 077440, aldA

aldehyde dehydrogenase AldA, putative

10

8

422

0.0385

3.35

R

[1]

[8]

[19]

[20]

[21]

SODC_ ASPFL

sodC

Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) - Aspergillus flavus

Ÿ Superoxide dismutases destroy toxic radicals which are normally produced within the cells

Ÿ Role in the resistance to phagocytic killing, but no decrease in virulence could be demonstrated for strains with mutations in three SOD genes in a murine IA model

2

2

82

0.0497

2.17

S

[1]

B0Y6Y9

Afu4g11580, sod2

Mn superoxide dismutase

4

4

137

0.0227

3.93

S

[8]

SODM_ ASPFU

sodB

Superoxide dismutase [Mn], mitochondrial precursor (AllergenAsp f 6)

6

6

273

0.0232

4.33

S

[1]

[20]

[22]

[23]

[24]

[25]

B0YAQ9

Afu5g11320

thioredoxin

Ÿ A. fumigatus thioredoxin proteins function as antioxidants during infection; impair neutrophil-mediated fungal killing; are required for fungal growth during infection of the cornea

Ÿ Thioredoxin reductase, a different protein involved in the thioredoxin pathway is named as a possible new target for antifungal therapy, and as a potential biomarker for serological diagnosis

Ÿ Thioredoxins are cross-reactive allergens involved in the pathogenesis of atopic eczema and asthma

Ÿ Thioredoxin and thioredoxin reductase are regulated by the AP-1 like bZip transcription factor Yap1, which is involved in the antioxidative stress response and antifungal drug resistance in C. albicans

3

2

58

0.0447

3.92

S

[8]

Q4WQZ2

Afu4g14530

glutathione s-transferase ure2-like protein, gstC

9

2

406

0.0011

349.13

Carbohydrate metabolic process

R

[1]

[16]

B0XM55

Afu6g13760

alpha-1,2-mannosidase subfamily

Transcript up-regulated in hyphae upon exposure to neutrophils

7

7

257

0.0078

4.16

S

[1]

B0XQJ8

Afu1g10790

alpha-1,2-mannosidase family

14

14

674

0.0000

2.84

R

[1]

B0YCI0

Afu7g04720

alpha-1,2-mannosidase, putative

4

4

190

0.0105

2.52