| Systematic name | Protein ID$ | Condition with abundance (p)* | Comment | Ref | |
| Afu5g09580 | Hydrophobin RodA | H6SWN9 | R (0.003) | Surface proteins important in adhesion to host. RodA is a virulence factor that masks Dectin-1 and Dectin-2 recognition of conidia, resulting in impaired neutrophil recruitment, neutrophil extracellular trap formation, increased fungal survival and clinical disease. RodA plays a role in the transfer of posaconazole to conidia. | [11] [12] [13] |
| RODL_ASPFU | R (<0.0001) | ||||
| Q8TFV2 | R (0.0001) | ||||
| Q8TFV8 | R (0.0002) | ||||
| Afu1g17250 | Hydrophobin RodB | B0XPA4 | R (0.0335) | ||
| Afu8g07060 | Hydrophobin, RodC | B0Y9E4 | R (0.0004) | ||
| Afu2g09290 | HSP60, putative (Chaperonin Cpn60 family) | B0XRX3 | S (0.0170) | Immune modulator: vaccine with rHsp60 from H. capsulatum and P. brasiliensis induces protection. Chaperonins participate in nucleotide excision repair. Other heat shock proteins (Hsp90) are suggested in mediating environmental influence on tandem repeat mutation rates. | [14] [15] [16] |
| Afu3g10490 | DNA damage response protein (Dap1) | B0XXV2 | S (0.0229) | S. cerevisiae ortholog Dap1p is required for cell cycle progression following damage, is involved in sterol regulation and directs resistance to itraconazole and fluconazole. | [17] |
| Afu2g01170, Gel1 | 1,3-Beta-glucanosyl transferase | GEL1 | R (0.0144) | GEL1 is the antigen eliciting the highest frequencies of specific T cells producing IFN-c (protective immune response mediating lysis of Aspergillus hyphae). Strenghtens cell wall assembly in stress. Expression is induced by voriconazole 0.5 mg/L | [18] [19] |
| Afu3g12120 | Fatty acid oxygenase ppoC | B0XX73 | R (0.0011) | The fatty acid oxygenases ppoA, ppoB and ppoC play an important role in host immune recognition and virulence and are important in integrating asexual and sexual spore balance. | [20] |
| Afu8g01050, Afl1 | Fucose-specific lectin | Q8NJT4 | S (<10−12) | AFL is suggested to be responsible for conidia attachment to the human lung epithelium. AFL is found in sera of ABPA patients, has proinflammatory effects and is a possible virulence factor. | [21] |
| Afu5g14740, FleA | Fucose-specific lectin | B0Y2N1 | S (0.0061) | Genes regulated by SrbA, which plays a role in ergosterol biosynthesis and resistance to azoles. -FleA may enhance attachment of spores to host cell membranes and contribute to pathogenicity. -Idi1 is connected to isoprenoid biosynthesis (precursors for biosynthesis of ergosterol) | [22] [23] |
| Afu4g09600 | GPI anchored protein, putative | B0Y6F1 | R (0.0012) | ||
| Afu6g11160, Idi1 | Isopentenyl-diphosphate delta-isomerase | B0Y8F7 | S (0.0061) | ||
| Afu4g11800, Alp1 | Alkaline protease 1 | ORYZ_ASPFU | R (0.0001) | Involved in immune evasion: cleaves C3, C4, C5, C1q and IgG, leading to down-regulation of complement activation at hyphal surface. Alp-deficient A. fumigatus caused drastically reduced mortality in an IA murine model, compared to the wild-type isolate (not confirmed in other reports). | [24] [25] |