Parameters

Phase 1

(Female)

n = 22

Phase 2

(Female)

n = 24

Phase 3

(Female)

n = 18

P value

F value

Remark

GLU (mmol/l)

3.71 ± 1.75

4.01 ± 1.08

4.21 ± 1.56

0.5535

0.597

NS

UREA (mmol/l)

4.24 ± 0.21^a

4.84 ± 0.54^b

5.15 ± 0.92^c

<0.0001

17.02

S

CRT (µmol/l)

168.8 ± 52.38

173.1 ± 63.45

188.6 ± 71.76

0.1772

1.781

NS

AST (U/L)

60.50 ± 22.07

65.67 ± 28.17

64.88 ± 21.47

0.7507

0.288

NS

ALT (U/L)

27.25 ± 11.05^a

30.76 ± 12.17^b

39.11 ± 19.97^c

0.0043

5.962

S

ALP (U/L)

27.95 ± 18.21

26.27 ± 7.84

27.77 ± 13.44

0.7529

0.285

NS