Sample full name

Sample short name

Preparation method

Kind of investigation

Comment

Withania somnifera sample

sample 2

Soxhlet extraction with ethanol, Methanol extraction

LC-MS

AS plant extracts and nutraceuticals were tested in previous studies with in vitro Amyloid Beta fibrillation measurements and found as an inhibitor of the fibrillation process dependent on which kind of Amyloid Beta: Aβ-40 (60% - 90%), Aβ-42 (80% - 90%) or M-Aβ-40 (33% - 60%) had been applied [10] [23] . The inhibition efficiency of the extracts was higher compared to the pure nutraceuticals.

Withania somnifera methanol

AS MeOH

Soxhlet extraction, evaporation of ethanol and solved in methanol

GC-MS

Withania somnifera maceration in 50% ethanol/warm MilliQ water mixture

AS EtOH warm water

Maceration

SFS

Withania somnifera maceration in 50% ethanol/MilliQ water mixture

AS EtOH water

Maceration

SFS

Withania somnifera maceration in 40% ethanol

AS EtOH 40

Maceration

SFS

Withania somnifera maceration in 50% ethanol

AS EtOH 50

Maceration

SFS

Withania somnifera maceration in MilliQ water

AS water

Maceration

SFS

Withania somnifera unsolved pure powder

AS powder

SFS

Withania somnifera maceration in 80% ethanol/20% MilliQ water mixture

AS EtOH

Maceration

SFS

Withania somnifera maceration in 96% ethanol

AS EtOH 96

Maceration

SFS

Bacopa monnieri

Sample 3

Soxhlet extraction with ethanol, Methanol extraction

LC-MS

BR plant extracts and nutraceuticals were tested in previous studies with in vitro Amyloid Beta fibrillation tests and found as inhibitors [10] [23] . Also here, the inhibition efficiency of the extracts turned out to be higher than for the nutraceuticals.

Bacopa monnieri methanol

BRMeOH

Soxhlet extraction, evaporation of ethanol and solved in methanol

GC-MS

Bacopa monnieri powder solved in 80% ethanol

BR powder EtOH

Powder solved in ethanol

SFS

Bacopa monnieri powder unsolved

BR powder

SFS

Bacopa monnieri powder in water solved

BR solution

Powder solved in MilliQ water

SFS

Bacopa monnieri fresh leave maceration extract

BR maceration

Maceration

SFS

Centella asiatica

Sample 1

Soxhlet extraction with ethanol, Methanol extraction

LC-MS

GK plant extracts and nutraceuticals were tested in previous studies, see above [10] [23] . Also here, the inhibitions of extracts were favored.

Centella asiatica methanol

GK MeOH

Soxhlet extraction, evaporation of ethanol and solved in methanol

GC-MS

Centella asiatica fresh leave maceration extract

GK maceration

Maceration

SFS

Centella asiatica powder solved in water

GK solution

SFS

Centella asiatica powder solved in EtOH

GK EtOH

SFS