Author

N (XYS vs. HRT)

Age

(years)

Outcome

Interventions

Duration

Adverse effects

Follow-up

Experimental

Control

Huang 2013 [21]

48/44

44.1

1) Response rate

2) single symptoms improvement

XYW (TID)

Estradiol (1 mg QD) + Medroxyprogesterone (8 mg QD)

8 weeks

R

N.R

Tang 2005 [22]

322/330

45 - 55

Response rate

XYW (BID)

Nilestriol (1 - 2 mg BIW)

8 weeks

R

N.R

Zhang 2014 [23]

21/21

50

Response rate

XYW (TID)

Estrogen (N.R.)

3 weeks

N.R.

3 months

Hu 2009 [24]

84/84

49.6

1) Response rate

2) FSH, E2, LH

DZXYS (QD)

Nilestriol (2 mg BIW)

12 weeks

N.R.

N.R

Yun et al. 2015 [25]

96/96

49.7

1) Response rate

2) Kupperman Score

DZXYS (BID)

Estrogen and progesterone (N.R.)

12 weeks

N.R.

N.R

Liu 2008 [26]

32/32

40 - 60

Single symptoms improvement

DZXYS (QD)

Premarin (0.3 mg TID) + Medroxyprogesterone (10 mg QD)

4 weeks

R

N.R

Zhou 1997 [27]

120/60

N.R.

Response rate

DZXYS (QD)

Stilbestrol (0.5 mg QD) + Medroxyprogesterone (4 mg BID)

12 weeks

N.R.

2 years

Wang et al. 2016 [28]

40/40

47 - 55

Response rate

JWXYS (TID)

Nilestriol (2 mg BIW)

N.R.

R

N.R

Zhang 2011 [29]

43/40

42 - 54

Response rate

JWXYW (TID)

Nilestriol (2 mg BIW)

8weeks

R

N.R