On admission

At the lowest oxygenation index time

Discharge from hospital

Moderate case

Severe case

P Value

Moderate case

Severe case

P Value

Moderate case

Severe case

P Valuea

P Valueb

Oxygenation index (mmHg)

452 (105)

329 (149.5)

0.000

452 (121.75)

234 (72)

0.000

481.5 (273)

374 (98.5)

0.002

0.000

Lactate (mmol/L)

1.75 (0.85)

1.9 (0.9)

0.88

1.7 (0.68)

1.95 (1.32)

0.040

1.7 (1.07)

1.7 (1.22)

0.388

0.54

White-cell count (×109/L)

5.3 (2.05)

5.5 (3.75)

0.79

6.0 (2.05)

8.05 (4.93)

0.006

6.0 (1.7)

6.95 (3.83)

0.000

0.21

Lymphocyte ratio (%)

25.75 (9.8)

23.6 (20.85)

0.041

25.5 (13.95)

11.55 (15.58)

0.000

25.3 (9.03)

19.9 (15.75)

0.459

0.000

Neutrophil ratio (%)

65 (14.43)

66.1 (27.25)

0.039

66.1 (16.12)

81.25 (21.8)

0.000

62.85 (11.9)

66.3 (15.38)

0.002

0.000

Platelet count (×109/L)

209 (62.5)

185 (128.5)

0.23

217.5 (73.25)

230.5 (111.25)

0.57

270 (100.5)

205.5 (100.25)

0.003

0.001

Alanine aminotransferase (U/liter)

18 (17.75)

30 (24)

0.032

18 (17)

28 (20.25)

0.005

20.5 (22.5)

26.5 (15.5)

0.136

0.27

Aspartate aminotransferase (U/liter)

22 (8.0)

31 (23.5)

0.001

24 (8.5)

23.5 (16.0)

0.29

21.0 (7)

22.0 (6)

0.989

0.053

Total bilirubin (μmol/L)

13.15 (9.42)

15.3 (13.55)

0.51

14.4 (7.18)

16.1 (15.4)

0.95

12.7 (4.78)

11.8 (7.55)

0.122

0.28

Direct bilirubin (μmol/L)

4.85 (3.38)

6.2 (5.6)

0.25

5.35 (2.45)

6.25 (6.10)

0.68

3.95 (1.5)

3.0 (2.6)

0.024

0.001

Indirect bilirubin (μmol/L)

8.15 (5.85)

9.1 (7.6)

0.67

9.0 (5.5)

10.20 (7.78)

0.90

8.7 (3.93)

8.15 (5.02)

0.239

0.91

Uric acid (μmol/L)

266 (128.75)

252 (170.5)

0.23

257 (139.5)

224 (128)

0.028

273 (116)

269.5 (95.25)

0.040

0.29

Creatinine (μmol/L)

77 (22)

73 (21)

0.77

78 (20)

73 (23.75)

0.38

76.5 (21.25)

69 (17.5)

0.242

0.036

Blood urea nitrogen (mmol/L)

4.18 (1.7)

4.19 (1.74)

0.55

3.84 (1.23)

5.03 (3.6)

0.044

3.41 (1.72)

3.78 (1.7)

0.023

0.53

Creatinine clearance rate (ml/min)

101.5 (22)

86 (19.5)

0.003

102 (15.75)

86 (18)

0.021

103.5 (28.75)

92 (18.5)

0.135

0.52