Variable

Newly diagnosed N = 55

On treatment

N = 30

Stop treatment N = 39

Healthy

N = 26

P value

EF

Mean ± SD

44.65 ± 7.52

41.7 ± 7.97

42.67 ± 6.82

64.5 ± 4.81

<0.0001

Mean (range)

44 (28 - 58)

43 (25 - 55)

42 (22 - 55)

65 (57 - 72)

P1 = 0.40, P2 = 1.00, P3 < 0.0001, P4 = 1.00, P5 < 0.0001, P6 < 0.0001

Degree of EF

Preserved EF

4 (7.27%)

0 (0.00%)

0 (0.00%)

19 (73.08%)

<0.0001

Mid-range EF

18 (32.73%)

11 (36.67%)

12 (30.77%)

7 (26.92%)

Reduced EF

33 (60.00%)

19 (63.33%)

27 (69.23%)

0

P1 = 0.32, P2 = 0.21, P3 < 0.0001, P4 = 0.61, P5 < 0.0001, P6 < 0.0001

NYHA Class

No dyspnea

0 (0.00%)

0 (0.00%)

0 (0.00%)

26 (100%)

Dyspnea with extra effort

0 (0.00%)

0 (0.00%)

0 (0.00%)

0

<0.0001

Dyspnea with normal effort

20 (36.36%)

13 (43.33%)

11 (28.2%)

0

Dyspnea with little effort

20 (36.36%)

5 (16.67%)

16 (41.03%)

0

Dyspnea at rest

15 (27.27%

12 (40.00%)

12 (30.77%)

0

P1 = 0.09, P2 = 0.37, P3 < 0.0001, P4 = 0.11, P5 < 0.0001, P6 < 0.0001