Parameters

Control I

(practically healthy animals), n = 7

Chronic ischemic heart damage

Control II

0.9% NaCl, n = 7

Main I

+ traditional treatment, n = 10

Main, II

+ Adenocin^®,

n = 11

Markers of endotoxemia

Optical density of plasma, λ = 282 nm

0.24 ± 0.04

0.81 ± 0.10

0.90 ± 0.14

0.29 ± 0.04^#

Optical density of erythrocytes, λ = 258 nm

0.58 ± 0.04

1.29 ± 0.10^**

0.92 ± 0.11^*#

0.56 ± 0.06^##++

VCAM1c

245 ± 24

651 ± 48^**

435 ± 23^*#

212 ± 29^##

TNF-α, pg/ml plasma

2.96 ± 0.21

12.8 ± 0.8^***

10.5 ± 1.1^*#

2.2 ± 0.3^###+++

TNF-α, pg/mg LV

2.2 ± 0.2

23.4 ± 1.3^***

20.9 ± 1.1^***

2.4 ± 0.4^###+++

NF-kB(p65) activity, o.u. at 450 nm

0.12 ± 0.04

0.30 ± 0.06

0.28 ± 0.18

0.14 ± 0.04^##++

Markers of tissue dysoxia

NAD, nMol/mg protein

6.8 ± 0.6

5.1 ± 0.6

5.3 ± 0.4

6.4 ± 0.5^###++

NADH, nMol/mg protein

6.3 ± 1.0

7.3 ± 0.8

7.0 ± 0.4

6.9 ± 0.5^###++

NAD/NADH ratio

1.08 ± 0.11

0.70 ± 0.06

0.76 ± 0.06

0.93 ± 0.05^###++

Lactate/pyruvate

2.83 ± 0.19

8.7 ± 0.6^*

7.8 ± 0.8^*

3.2 ± 0.6^##++

Markers of tissue intrinsic defense systems reserve

Antioxidant

Velocity of ${\text{O}}_2^{-}$ generation, mMol/mg protein×min

39 ± 11

98 ± 18^**

116 ± 13^*#

44 ± 9^##

Hydrogen peroxide, pmol/min×mg

89 ± 11

198 ± 28^**

121 ± 23^*#

79 ± 9^##

Lysosomal

Free Catepsin D activity, mmol thyrosine/mg protein min

5.5 ± 0.7

11.8 ± 1.3^***

10.4 ± 1.4^***#

6.9 ± 0.3^###++

Total Catepsin D activity, mmol thyrosine/mg protein min

4.5 ± 0.7

5.9 ± 1.4^***

5.4 ± 1.1^***#

5.1 ± 0.6^###++

Lysosomal integrity

0.82 ± 0.06

0.50 ± 0.04^***

0.52 ± 0.05^***

0.74 ± 0.06^###++